Phototoxicity is a toxic response from a substance applied to the body which is either elicited or increased after subsequent exposure to light, or that is induced by skin irradiation after systemic administration of a substance.
International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), has issued draft Guidelines ICH S10 on Photosafety Evaluation of Pharmaceuticals. According to these guidelines, phototoxicity testing may be required for the risk evaluation of compounds seeking market authorization.
Nucro-Technics can perform phototoxicity (OECD 432) and photogenotoxicity (chromosome aberration and Micronucleus) assays in compliance with Good Laboratory Practices.
We recognize that our clients have particular testing needs; we would be pleased to work with you to customize a protocol that will meet your budget and scientific requirements.