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Toxicology Services - Acute Toxicity Testing, Subacute Toxicity Testing, Chronic Toxicity Testing, multi-species testing, oecd guidelines


NUCRO-TECHNICS‘ long experience with regulatory guidelines and with a variety of therapeutic agents and industrial chemicals makes us the logical choice for your GLP-compliant safety and toxicology needs. NUCRO-TECHNICS offers comprehensive experience in pre-clinical and research services to determine the safety evaluation of substances for government agencies, as well as clients in the pharmaceutical, chemical, biotechnology, petroleum, and device industries.

Study protocols designed at NUCRO-TECHNICS comply with the requirements of Canadian, U.S. and international regulatory agencies including, but not limited to, Health Canada, the U.S. FDA, EPA and others. We also provide a wide variety of biological assays in accordance with the USP, EP, BP, and JP.

Our testing includes general mammalian toxicology and we can perform the full spectrum of acute, bioavailability / pharmacokinetic, subchronic, and chronic studies typically required for new pharmaceuticals and biotechnology products. In addition, we can test biomedical engineering products and medical devices in a variety of protocols. Protocol design, whenever possible, is based on regulatory requirements. Studies are performed in compliance with Good Laboratory Practices (GLPs) and/or Good Manufacturing Practices (GMPs) in rodent and non-rodent species.

NUCRO-TECHNICS also provides a broad spectrum of general and specialized Clinical Pathology Analysis, and specialized histological services for veterinary and industrial research. A variety of haematoxylin and eosin and special stain techniques for diagnostic pathology, as well as specialized histochemistry and immunohistochemistry techniques are available for research purposes.

Validated software provides a reliable set of tools that automates data management throughout the various phases of different studies.

The following service offerings are available:

Acute Toxicity Studies
  • Acute toxicity tests (all routes)
  • Dermal and Eye Irritation Studies
  • Dermal Sensitization (multiple methods available)
  • Vaginal Irritation Studies
  • Pharmacokinetic (PK)/ Pharmacodynamic (PD) Studies
Subacute Toxicity Studies
  • Dose range-finding studies
  • 14-day toxicity studies: Repeated dermal and ocular studies
  • 28 to 90-day toxicity studies
Chronic Toxicity Studies
  • 6, 12, 18, and 24-month toxicity studies in rodents and non-rodent species (i.e. canines and minipigs)
Other Studies
  • Cardiovascular, Respiratory, and CNS Safety Pharmacology
  • Assessment of Carcinogenicity in p53 +/- mice
  • Bioassay Studies
Clinical Pathology Services
  • Clinical Chemistry
  • Coagulation Tests (Hemostasis)
  • Haematology
  • Parasitology
  • Urinalysis
  • Cytology
  • ELISA (Enzyme-linked Immunosorbent Assay)
Histopathology Services (Pathology)
  • Immunohistochemistry
  • Histology (Grossing, Processing, Embedding, and Sectioning)
  • Paraffin Services
  • Microtomy
  • Staining
  • Microscopy
  • Photography
Support Services

All work is done to the appropriate standards, and subjects are maintained according to the requirements of the Animals for Research Act (Ontario), the Guidelines of the Canadian Council on Animal Care (CCAC), and the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).

For further information, to receive a quotation, or to schedule a test, please contact NUCRO-TECHNICS.